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S/N
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Section
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Question
|
answer
|
|
1
|
Title and abstract:
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Study’s design in the title/abstract indicated
|
|
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2
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Background/Rationale:
|
Informative/balanced summary of methods and key results provided in
the abstract
|
|
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3.
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Objective:
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Scientific background and rationale for reported investigation
clearly explained
|
|
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4.
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Study design:
| Key elements of the study design presented |
|
|
5.
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Setting:
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The setting, locations, dates, periods of recruitment, exposure,
follow-up, and data collection clearly described
|
|
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6.
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Participants:
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Study type, Eligibility/matching criteria, participants selection,
case ascertainment, control and follow
up methods/source, number of exposed, unexposed, and controls per case
|
|
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7.
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Variables:
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All outcomes, exposures, predictors, potential confounders, and
effect modifiers; diagnostic criteria, clearly defined
|
|
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8.
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Data source/measurement:
|
Sources of data, methods of
assessment (measurement); describe comparability of assessment method(s) given
in detail
|
|
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9
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Bias:
|
Efforts to address likely sources of bias defined
|
|
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10.
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Study size:
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How the study size was derived clearly outlined
|
|
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11.
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Quantitative variables
|
How quantitative variables were analyzed include which groupings were
chosen and why
|
|
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12.
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Statistical methods:
| All statistical methods, including those used to control for confounding, examine subgroups and interactions, address missing data, loss to follow-up, matching of cases and controls, analyze sampling strategy and sensitivity explained |
|
|
13
|
Participants:
| Numbers of individuals potentially, examined or confirmed eligible at each stage of the study and those included in the study or completing follow-up, and reasons for nonparticipation are clearly defined, Consider the use of a flow diagram |
|
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14.
|
Descriptive data:
|
Characteristics of study participants (e.g., demographic, clinical,
social) and information on exposures and potential confounders, number of
participants with missing data for each variable of interest, summarize
follow-up time (e.g., average and total amount) clearly defined
|
|
|
15.
|
Outcome data:
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Numbers of outcome events or summary measures over time, numbers in
each exposure category, or summary measures of exposure and numbers of outcome events or summary
measures, outlined
|
|
|
16.
|
Main results:
| Have you given unadjusted estimates and, if applicable, confounder-adjusted estimates and their precision (e.g., 95% confidence interval); make clear which confounders were adjusted for and why they were included, report category boundaries when continuous variables were categorized. |
|
|
17
|
Other analysis:
|
Subgroups, interactions, and sensitivities reported
|
|
|
18.
|
Key results:
|
Key results in relation to study objectives reported
|
|
|
19
|
Limitation:
|
limitations of the study, taking into account sources of potential
bias or imprecision; discuss both direction and magnitude of any potential
bias
|
|
|
20.
|
Interpretation:
| Give a cautious overall interpretation of results considering objectives, limitations, the multiplicity of analyses, results from similar studies, and other relevant evidence |
|
|
21
|
Generalizability:
|
Discuss the generalizability (external validity) of the study results
|
|
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22.
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Funding:
|
the source of funding and the role of the funders for the present
study and, if applicable, for the original study on which the present article
is based Funding
|
|
